At Houston Methodist, the Postdoctoral Fellow position is responsible for performing basic research duties under the supervision/direction of a Physician and/or Principal Investigator (PI). This position may work in a laboratory setting or may consist of computer work that supports the department's research mission. Preferred candidates to have experience in cancer molecular biology, cancer mouse models, cancer pharmacology and/or immuno-oncology and a sincere interest in translational research for the benefit of cancer patients.
The Rostomily-Mikheev Lab at the Houston Methodist Research Institute is seeking a post-doctoral fellow to establish the role of novel dual NR4A1 and NR4A2 nuclear orphan receptor inhibitors in glioblastoma (GBM). NR4A1/2 drives crosstalk between immune suppression and EMT and their inhibition is hypothesized to overcome resistance to immune checkpoint blockade and standard TMZ/XRT therapies by concurrently reprogramming the mesenchymal and immune suppressive tumor microenvironment. The candidate will be involved in quantifying the effects of NR4A1/2 inhibition on reprogramming the GBM TME in syngeneic models using multiple approaches including scRNAseq, spatial IHC and transcriptomics and bioinformatic modeling to measure TME changes. The role of NR4A1/2 regulated targets, TWIST1 and PD-L1, in TME modulation and treatment responses will be defined through gain and loss of function studies. These studies are expected to support clinical development of the NR4A1/2 drugs as standalone or adjuvant therapies to potentiate current standard of care and/or immune checkpoint treatment in GBM.
The position is open and available for starting immediately. The project is funded through a recently awarded R01 “Pharmacologic targeting of NR4A1 and NR4A2 to activate glioblastoma treatment response” (1R01NS129720) in collaboration with Dr Steven Safe at Texas A&M who developed the drugs and has expertise in NR4A1/2 in cancer. Competitive candidates are expected to have experience in cancer molecular biology, cancer mouse models, cancer pharmacology and/or immuno-oncology and a sincere interest in translational research for the benefit of cancer patients.
Requirements:
PEOPLE ESSENTIAL FUNCTIONS
SERVICE ESSENTIAL FUNCTIONS
QUALITY/SAFETY ESSENTIAL FUNCTIONS
FINANCE ESSENTIAL FUNCTIONS
GROWTH/INNOVATION ESSENTIAL FUNCTIONS
This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.
Qualifications:
EDUCATION
WORK EXPERIENCE
LICENSES AND CERTIFICATIONS - REQUIRED
KNOWLEDGE, SKILLS, AND ABILITIES
SUPPLEMENTAL REQUIREMENTS
WORK ATTIRE
ON-CALL*
*Note that employees may be required to be on-call during emergencies (ie. DIsaster, Severe Weather Events, etc) regardless of selection below.
TRAVEL**
**Travel specifications may vary by department**
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